Epigenetic Modification in Coronary Atherosclerosis

A study of iron status in patients with coronary atherosclerosis

Background: It has been demonstrated that free oxygen radicals have a close interaction with lipid peroxidation, causing a modification of low-density lipoproteins (LDL) and facilitating LDL deposition, with the consequent formation of atherosclerosis plaques. Free radical production is catalyzed and accelerated in the presence of iron. This study was conducted to evaluate the possible associ...

Emerging epigenetic maps in atherosclerosis.

Apolipoprotein E Gene Polymorphism in Iranian Coronary Atherosclerosis Patients Candidate for Coronary Artery Bypass Graft

  Objective(s): Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the Apolipoprotein E genotypes with coronary artery disease in the Iranian population.   Materials and Methods: The Apolipoprotein E genotype in DNA samples extracted from 66 CAD+ patients and 61 control s...

Epigenetic Modification of Plant Chromatin

Based on the analysis of 20 different monocot and eudicot species, we propose that the centromeric distribution of the phosphorylated histone H2AThr120 is evolutionary highly conserved across species with monoand holocentric chromosomes. Therefore, antibodies recognizing the phosphorylated threonine 120 of the histone H2A can serve as a universal marker for the cytological detection of centrome...

Coronary atherosclerosis in Nigeria.

The relative rarity of ischaemic heart disease in the negro is well recognized, but there are very few morphological studies on the quantitative or qualitative aspects of the disease. Of 8,ooo necropsies carried out in the University College Hospital, Ibadan, over a io-year period, there were IO Nigerians with proven myocardial infarcts. Of these, 4 were on the basis of coronary embolism from e...